Dear friend, thank you for your questions. Chromosomal anomalies in the male and female are diagnosed through Karyotyping (blood test) which is quite easy. If the male has a chromosomal anomaly, the anomaly passes into the sperm with the exception of mosaicism (where only a proportion of sperm would have the anomaly). Therefore the anomaly would be inhereted in the embryos either it is an egg donation or a natural cycle. Karyotyping of sperm (FISH) would indentify the proportion of sperm carrying the anomaly (mosaicism or not). In case of non-mosaicism the entire sperm count carries the anomaly and should not be used but instead turn to sperm donation. In case of mosaicism a preimplantation diagnosis of embryos is needed in order to identify those with a chromosomal anomaly that should be excluded from embryo transfer. Failure in the first attempt in egg donation cycles should not disappoind you as pregnancy rates are 50-60% for each cycle and there is always the probability of failure. Success in the second attemp seems to be around 50-60% as well for each cycle. Thank you once more for your question and wwe are always at your disposal for any further queiries you might have.